Biomedical Sciences Research Centre "Alexander Fleming" 1 article published in JoVE Neuroscience Transplantation of Chemogenetically Engineered Cortical Interneuron Progenitors into Early Postnatal Mouse Brains Myrto Denaxa1,2, Guilherme Neves3, Juan Burrone3, Vassilis Pachnis1 1Nervous System Development and Homeostasis Laboratory, The Francis Crick Institute, 2Neuroscience Centre, Biomedical Sciences Research Centre "Al. Fleming", 3 Here we present a protocol, designed to use chemogenetic tools to manipulate the activity of cortical interneuron progenitors transplanted into the cortex of early postnatal mice.